Tough defense by Louisville led to the defeat Thursday night of Michigan State in the NCAA men's basketball tournament, NPR's Mike Pesca .
The Spartans, who lost to Louisville 57-44, are the first of the four No. 1 regional seeds to be sent home.
Syracuse, another No. 1 seed, managed to hang on with a 64-63 win over Wisconsin. In Thursday's other two games, Florida beat Marquette 68-58 and Ohio State thumped Cincinnati, 81-66.
Play resumes tonight to see which other teams make it into the "Elite Eight."
Among the many places to see the bracket: .
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Mike Pesca on 'Morning Edition'