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Every COVID-19 metric looks a little more hopeful compared to a few weeks ago. Cases are down. So are hospitalizations. Yet state health officials worry about wild cards, like the omicron variant, and say a cautious approach could help prevent numbers from taking another turn for the worse.

State health officials say more than 10,000 people have died from COVID-19 in Colorado. The grim milestone comes on the one-year anniversary of the first shipment of the Pfizer vaccine arriving in Colorado and about 21 months into the pandemic, The Denver Post reported Tuesday. It also comes on the same day the U.S. death toll from COVID-19 topped 800,000.

The state’s opt-in COVID-19 exposure notification system has been around for a year, but a system upgrade — combined with the latest wave of cases — recently made for a busy few weeks for the app.

Colorado became the third U.S. state to detect a case of the omicron variant in a woman who had recently traveled to Africa, state health officials announced Thursday.

The U.S. is in the midst of another COVID holiday season, and federal laws that offered COVID-related paid sick leave to workers have expired. Colorado, Los Angeles and Pittsburgh are among a small number of places that have put in place their own COVID protections, but many sick workers across the country must wrestle with difficult financial and ethical questions when deciding whether to stay home.

The new shots from Moderna and Pfizer-BioNTech target both the original strain of the coronavirus and the omicron BA.4/BA.5 subvariants that most people are catching now.

Americans' life expectancy dropped for the second year in a row and is the biggest drop since the 1920s. COVID-19 is driving the downward trend, according to CDC data.

The Food and Drug Administration is planning to authorize a new generation of COVID-19 boosters this week that for the first time will target the omicron variant.

The Biden administration is pausing its distribution of free COVID-19 tests this week, but you can still order new ones before the end date.

These days the world of at-home testing for COVID-19 is confusing. How often do I need to test to see if I'm really positive — or negative? Does a faint line mean I'm less contagious?

The vaccine maker alleges that its rivals Pfizer and BioNTech used some patented features of its mRNA technology to develop their COVID vaccines.